34^th International Conference on Vaccines and Immunization October 03-04, 2022 London, UK

Biography:

Over 40 years experiences in public health and infection disease epidemic control. Lead a team (EMO Biology Inc.) of scientists conducted the COVID-19 related studies including immunology, virology, epidemiology, serological and clinical providing understanding of root cause of global pandemic and control methods since 2020 up to now. Prior to 1991, Former officer of national immunization program of China, WHO’s Fellow, CDC infectious diseases control specialists and epidemiologist. Multiple National Academical rewards from the contribution to the clinical and epidemiological study lead to the research of typhoid infectious and discovered the new wildlife carrier of such disease-causing specific population infectious in a local outbreak and disease put off in 1985. Lead national EPI program with setting up computerized disease reporting system for children’s infectious diseases control through immunization (1989). Lead the clinical serological, and epidemiological studies resulted in national policy adaptation for senior booster immunization of tetanus in 1996 USA.

Abstract:

Background: Molecular evidence has shown poliovirus vaccination induces an adaptive humoral immune response. In vitro experiments of polio-immune sera have been examined retrospectively in the context of the COVID-19 pandemic, but the induced antibodies that may cross-react with SARS-CoV-2 have yet to be analyzed in a controlled and prospective manner.

Objective: To evaluate and characterize the immune response to SARS-CoV-2 elicited in adults by IPV (inactivated poliovirus vaccine).

Design: Single arm, open-label, pre-post vaccine immunogenicity trial

Setting: San Diego, CA (USA), November 2020 on going.

Participants: Adults between the ages of 18-80 with no active infectious disease, history of COVID-19 or prior COVID-19 vaccination.

Interventions: All participants received IPV (IPOL, Sanofi Pasteur) by intramuscular injection.

Measurements: Blood specimens collected at baseline (pre-inoculation) and 28±3 days post-inoculation were tested for polio antigens using Enzyme-Linked Immunosorbent Assays (ELISA). Viral replication via RNA-dependent RNA polymerase (RdRp) enzymatic activity was measured to the polio-immunized sera.

Results: A total of 298 of the 300 enrolled participants completed both on-site visits. Comparing the baseline (Day 1) and Day 28 measurements, 261 of the 298 paired samples (87.6%) demonstrated a positive increase in antibody titers, 30 (10.1%) decreased and 7 (2.3%) had no change. Samples that demonstrated no change or a decrease in titers from pre- to post-inoculation had high titer levels at baseline. Of the 298 polio-immune serum samples, 47 were randomly selected for RdRp enzymatic activity testing, and all samples (100%) demonstrated inhibition of RdRp function, inhibition of SARS-CoV-2-induced Cyto Pathic Effects (CPE) in Vero cell culture, and a clear demonstration that IPV immunization raises antibodies that recognize the RNA-dependent-RNA-polymerase (RdRp) proteins of both poliovirus and SARS-CoV-2. Additionally, our retrospective study demonstrated adults re-immunized with IPV exhibited similar antibody responses to both poliovirus and SARS-CoV-2 RdRp, compared to children who received IPV as part of their childhood vaccinations. Across all ages, poliovirus vaccination produces antibodies that inhibit RdRp function, thereby preventing viral replication that may cause disease progression in infected individuals. The study results provide robust data that poliovirus vaccines can generate strong adaptive immune responses against SARS-CoV-2, providing protection from infection. Serologically, we found poliovirus vaccination significantly increases antibody titers (p<0.0001). Clinically, only 1.67% of the studied population reported testing positive for COVID-19, which can be compared to the local infection rate among the general population at that time, 8.83% (p<0.0001, z=4.677 [95% CI (0.54,3.85)]). Those who did test positive for COVID-19 only experienced mild symptoms for 1-3 days, if at all. Moreover, no one in the clinical trial was hospitalized (0%) or died (0%) due to COVID-19, which may be compared to the rates in the local population, with 5.5% of the general public being hospitalized and 1.3% dying from COVID-19 (p<0.0001, z=6.21; p<0.01, z=2.73, respectively).

Limitations: Participants were not routinely tested for COVID-19, though known exposures were reported, and COVID-19 PCR results were documented.

Conclusion: A single dose of IPV induces a significant increase in antibody titers, which can cross-react with SARS-CoV-2. This prospective clinical trial confirms findings from retrospective studies that polio-immune sera demonstrate inhibition of viral replication and IPV can affect SARS-CoV-2 RdRp reactivity.

Biography:

I am  Dr Kunal Joon ( MSc in genetics and virology) studying virus for 5 years and discovered it living and found its treatment

Abstract:

DNA forward rolling

Activation all dominant gene on dna

DNA backward rolling

Activation of all recessive gene on DNA

RNA forward rolling

Studying m RNA formed due to forward rolled dna

RNA backward rolling

Studying m RNA formed due to backward rolled dna

Introduction of nuclear medicine :

Nuclear medicine is made up of the glucose fats proteins and vitamins, huge amount of immune cells with iron oxide. The glucose fats breakdown and release energy, proteins and vitamins build up and repair damaged tissue. Immune cells released in body build up and divide the other immune cells and fight against virus and its infection.

Nuclear medicine affect the virus by increasing and repairing immunity of body by increasing energy in body and by building up the immune cells

An animal who is affected by the virus should take two times a nuclear medicine in an hour, as because immune system takes large time to repair.

Benefits of nuclear medicine:

Nuclear medicine increases the immunity of the body and also some amount of temperature.

Nuclear medicine increases the energy of the body and build up the body muscles.

Side effect of nuclear medicine:

Taking large amount of nuclear medicine can lead to increase the large amount of temperature and can even lead to dehydration.

The nuclear medicine increases the immunity, energy in the body and even increases the temperature of the body and even build up the immune system strong and even body capacity to fight against the infection

Nuclear medicine design

Energy doses

It is used to maintain energy balance in patients bodies and level the patients energy .

Antibodies

This is used to treat virus and kill it

It is used to kill the virus .

Desiging monoclonal antibodies

Antibodies are designed by

DNA forward rolling and DNA backward rolling

We take a particular gene from virus which kills or resists the viral Infection.

Treatment of any virus or viral

Disease can be done through this

Medicine.

Biography:

Aondover Eric Msughter, a Doctoral student at BUK is a communication scholar. He obtained a Master of Science Degree (M.Sc) in Mass Communication from Bayero University, Kano and Bachelor of Science Degree (B.Sc) in Mass Communication from the same University. He has published papers in several national and international scholarly journals and attended and participated in several conferences and workshops on communication, media and journalism. He is a member of Association of Communication Scholars & Professionals of Nigeria (ACSPN), African Council for Communication Education (ACCE), and Social Science Research Council (FSSRC), USA and an Award Winner of Campus Journalism as “Syndicated Writer”, 2018 and “Book Author”, 2019.

Abstract:

Fake news with local and global dimensions is everywhere. Africans are targeted by blatant lies, hoaxes, conspiracies, and misinformation being peddled as news on legitimate sites. It can be mixed with truth to create controversy, which in the digital era can be spread wide with immeasurable consequences. Journalism appears to be in an existential crisis stoked by a continuously evolving ecology, complicated or enhanced, depending on the argument, by the dynamics of digital technology and communication. This character of the media ecology has had collateral consequences, with the focus on the subject of fake news trending in discourse and contestations in the public sphere, terrestrial or virtual. Such focus furthers the larger discussion on media content which are portrayals of reality but are not necessarily accurate in their reflection of relationships in journalism and health domains. The media are therefore arena for the coloration of reality through the prism of sources and gatekeepers driven by agendas and a worldview encapsulated in frames, which are value-laden. Fake news or misinformation is a problem in every African country, especially in this era of Covid-19. It is within this context, that the attention to media literacy around those lacking the requisite literacy to guide safe consumption of fake news has gained prominence. The outbreak of the Coronavirus Disease of 2019 (Covid-19) and its escalation to a global pandemic posed threat to public health worldwide. Although availability and acceptance of Covid-19 vaccination is a crucial step to cushioning the pandemic, hesitancy tends to hamper the success of the vaccination. As a result, many could not accept the vaccine with different notions that the vaccine is a conspiracy to reduce population, and it can lead to infertility. As a result of fake news on the vaccine, many also believe that the government is using it to generate money, it can cause dizziness, and it can make someone run mad, among others. Therefore, the challenge of fake news in Nigeria points to the need for a coordinated response by governments and other stakeholders. Media education and digital literacy are urgently needed. The private and third sectors will need to invest in initiatives to tackle the problem to promote accuracy in media in Nigeria. This implies that Nigerians must come together against fake news on the Covid-19 vaccine.